Dean in
the Canadian
Dean O. Kuethe, Ph.D.
New
Mexico Resonance, 2301 Yale Blvd. SE, Suite C-1, Albuquerque, NM 87106 dkuethe at NMR.org (505) 244-0017
Born
8 Sept. 1956
Current Research
Imaging lungs
and inert fluorinated gases in lungs with nuclear magnetic resonance (NMR) to
provide superior images of disease and physiological parameters like
ventilation and perfusion. Both
the NMR imaging of living lung parenchyma and imaging of gases in lungs at
thermal equilibrium polarization were previously widely known to be
impossible. They can eliminate the risk
from ionizing radiation so that physicians may image lungs frequently and
provide additional tools for discrimination of tissue types to improve
pulmonary diagnoses.
Measuring pore sizes by
measuring the NMR relaxation of inert fluorinated gases. The distribution of pore sizes in the 0.5 to
30 nanometer range is highly sought in porous catalysts, filters, and
insulation.
Imaging defects in materials,
such as cracks in statues, bubbles in epoxy glues, and aging of plastics.
Current Additional Interest
Designing
high fuel-efficiency vehicles that get over 85 km per liter (200 miles per
gallon). Rather than beginning
with the mind set of a car, if one adds a small, efficient engine to something
akin to a well-suspended, human-powered vehicle, it could achieve highway
speeds and car-like hill climbing performance while still achieving 130 km/l (305
mpg) on the highway, and 190 km/l (440 mpg) in the city. Such a vehicle is not available, but the
market may be ready for it in the near future.
Previous Key Accomplishments
Answered a 60
year old puzzle: why air flows in same direction through bird lungs during both
inspiration and expiration in the absence of mechanical valves.
Developed
theory and methods for measuring turbulent diffusivity and intensity with NMR
imaging, an improvement over laser-Doppler anemometry for engineering fluid
mechanics.
Employment History and
Education
Scientist,
Associate Scientist,
Lovelace Respiratory Research Institute (f.k.a., The Lovelace Institutes,
f.k.a. Lovelace Medical Foundation), April 1994 through September
1999. NMR imaging, respiration
physiology, fluid mechanics
Scientist and Manager, Massachusetts
Institute of Technology, Nuclear Magnetic Resonance Imaging Facility,
Francis Bitter National Magnet Laboratory,
December 1989 to November 1993.
Developed theory and methods
for measuring anisotropic turbulent diffusivity, turbulent intensity, and
correlation times with NMR imaging
Senior Scientist,
Developed mathematical model of
drug capsules that burst at predetermined times by dialysis.
Research Associate,
Developed
theory and methods for measuring turbulent diffusivity.
Determined
safety of non-ferromagnetic retinal tacks in NMR imaging.
Taught
seminar, magnetic resonance and fluid mechanics; mini course, theoretical
calculus.
Ph.D.
1986
Major Professor: Knut
Schmidt-Nielsen
Dissertation: Fluid Mechanical
Valving of Air Flow in Bird Lungs
Answered a 60 year old puzzle
of why air flows in same direction through lung during both inspiration and
expiration in the absence of mechanical valves.
Research Assistant,
Discovered neurological damage
caused by radiosensitizing drug misonidazole in rats that resulted in F.D.A.
ban of the drug.
Research Assistant, State University
of New York College of Environmental Science and Forestry at Syracuse, Dept. of Zoology, March
through June 1978.
Studied
nesting habits and breeding success of ravens in the
B.S. 1977 magna cum laude State University of New York College of
Environmental Science and Forestry at
Majors: Wildlife Ecology and
Comparative Physiology
Skills and Expertise
Novel approaches to problem
solving that include bridging disciplines such as biology, mathematics,
physics, medicine, and engineering.
Design and
manufacture of apparatuses that work.
Woodworking and blacksmithing
as a professional and as a serious amateur. Design and
manufacture of furniture and tools.
Excellent writing, lectures,
and presentations; reading knowledge of German; 35 years computer programming.
Publications
Adolphi, N. L., and D. O. Kuethe. 2008 Quantitative mapping of
ventilation-perfusion ratios in lungs by 19F MR imaging of T1
of inert fluorinated gases Magnetic Resonance in Medicine. (accepted).
Kuethe, D.
O., N. L. Adolphi, and
Kuethe, D. O., R. Montaño, and T. Pietraß. 2007 Measuring nanopore size from the
spin–lattice relaxation of CF4 gas. Journal of
Magnetic Resonance. 186(2):243–251.
Kuethe, D. O., M. D. Scholz, and P.
Fantazzini. 2007 Imaging inert fluorinated gases in
cracks: perhaps in David's ankles. Magnetic Resonance Imaging 25:505-508.
Kuethe, D. O., and M. D. Scholz. 2007 Imaging cracks in marble with magnetic
resonance imaging of inert fluorinated gases. Applied
Magnetic Resonance. 32:3-12.
Kuethe, D.
O., T. Pietraß
and V. C. Behr. 2005 Inert fluorinated gas T1
calculator. Journal of Magnetic Resonance.
177:212-220.
Alam, T.
M., M. Celina, J. P. Collier, B. H. Currier, J. H. Currier, S. K. Jackson, D.
O. Kuethe, G. S. Timmins. 2004. g-Irradiation of ultrahigh-molecular-weight
polyethylene: electron paramagnetic resonance and nuclear magnetic resonance
spectroscopy and imaging studies of the mechanism of subsurface oxidation. Journal
of Polymer Science: Part A: Polymer Chemistry. 42:5929–5941.
Beyea, S. D., S. L. Codd, D. O. Kuethe and
Kuethe, D.
O., V. C. Behr, S. Begay. 2002. Volume of rat lungs measured throughout the
respiratory cycle using 19F NMR of the inert gas SF6. Magnetic Resonance in Medicine. 48(3):547-549.
Caprihan, A.,
C. F. M. Clewett, D. O. Kuethe,
Kuethe, D.
O., A. Caprihan, H. M. Gach, I. J. Lowe, and
Loeppky, J.
A., D. O. Kuethe, S. A. Altobelli, P. Scotto, and J. Piiper. 1999 Effects of gas density on
experimentally obstructed ventilation during acute hypoxia. Respiration Physiology.
117:151-160.
Kuethe, D. O., A. Caprihan,
Gach, H. M., I. J. Lowe, D. P.
Madio, A. Caprihan, S. A. Altobelli, D. O. Kuethe, and E. Fukushima. 1998.
A programmable pre-emphasis system. Magnetic
Resonance in Medicine. 40(3):427-431.
Kuethe, D.
O., A. Caprihan,
Kuethe, D.
O., and J.-H. Gao
1995. NMR signal loss from
turbulence: models of time dependence compared with data. Physical Review E. 51(4):3252-3262.
Kuethe, D. O.
D. C. Augenstein, J. D. Gresser, and D. L. Wise. 1992.
Design of capsules that burst at predetermined times by dialysis. Journal of Controlled Release. 18:159-164.
Kuethe, D. O., K. W. Small,
& R. A. Blinder. 1991. Non-ferromagnetic retinal tacks are a
tolerable risk in magnetic resonance imaging. Investigative
Radiology. 26(1):1-7.
Kuethe, D. O. 1991.
Confusion about pressure. The Physics Teacher.
29(1):20-22.
Kuethe, D. O. 1989. Measuring distributions of
diffusivity in turbulent fluids with magnetic resonance imaging. Physical Review A. 40(8):4542-4551.
Kuethe, D. O. & R. J.
Herfkens. 1989. Fluid shear and spin echo images. Magnetic Resonance in
Medicine. 10(1):57-70.
Evans, A. J., R. A. Blinder, R.
J. Herfkens, C. E. Spritzer, D. O. Kuethe, E. K. Fram, & L. W.
Hedlund. 1988. Effects of turbulence on signal intensity in
gradient echo images. Investigative Radiology.
23(7):512-518.
Kuethe, D. O. 1988.
Fluid mechanical valving of air flow in bird lungs. Journal
of Experimental Biology. 136:1-12.
Kuethe, D. O. 1986.
Fluid mechanical valving of air flow in bird lungs. Ph.D.
dissertation,
Abstracts of presentations,
newsletters, etc.:
Kuethe, D. O. and M. D. Scholz, Imaging inert
fluorinated gases in cracks — perhaps in David's ankles, 8th International
Bologna Conference on Magnetic Resonance in Porous Media,
Kuethe, D. O. and M. D. Scholz, Detecting cracks by
imaging inert fluorinated gases, 8th International Conference on Magnetic
Resonance Microscopy,
Kuethe, D. O. and A. F.
McDowell, Measuring nanopore sizes with the T1 of CF4, 8th International
Conference on Magnetic Resonance Microscopy,
Kuethe, D. O. and N. L. Adolphi, Imaging SF6 and
C2F6 gases in lab rat lungs: To avoid cooking larger animals, use C2F6, 8th
International Conference on Magnetic Resonance Microscopy,
Kuethe, D. O. and N. L. Adolphi, Lung tissue: for
good resolution, keep acquisition time even shorter than 2T2*, 8th
International Conference on Magnetic Resonance Microscopy,
Adolphi, N. and D. Kuethe, Imaging V/Q in lungs by mapping 19F T1 of
Inert Fluorinated gases, 8th International Conference on Magnetic Resonance
Microscopy, Mibu, Japan, Aug. 2005.
Yamaguchi, M., K. Suzuki,
Sillerud, L. N. Adolphi, R.
Serda, M. Bisoffi, and D. Kuethe, Development of targeted contrast agents for
MRI of prostate cancer, 8th International Conference on Magnetic Resonance
Microscopy, Mibu, Japan, Aug. 2005.
Kuethe, D. O., Imaging ventilation-to-perfusion
ratios with NMR imaging of inert fluorinated gases, International Workshop on Pulmonary
Functional Imaging at Penn,
Serda R. E., M. Bisoffi, N. L.
Adolphi, D. O. Kuethe, and L. O. Sillerud, Molecular MR imaging of human prostate
cancer cells labeled with superparamagnetic nanoparticles conjugated to
anti-PMSA antibodies. AACR Basic, Translational, and Clinical Advances in
Prostate Cancer Special Conference, ,
McDowell, A. F. and D. O.
Kuethe, Spin-lattice
relaxation of fluorinated gases in pores.
7th International Conference on Magnetic Resonance in Porous Media,
Adolphi, N. L. and D. O.
Kuethe, V/Q mapping using inert fluorinated gas T1s. International Society of Magnetic Resonance
in Medicine,
Kuethe, D. O.,
N. L. Adolphi, and R. E.
Montaño, Pulmonary MRI without
Hyperpolarized Gases. Lovelace Respiratory Symposium: New Therapies and
Diagnostic Techniques for Respiratory Disease,
Bredow, S., D. O. Kuethe, D.
Esparza, and K. K. Divine,
Diagnostic imaging of lung cancer by MRI. Lovelace Respiratory
Symposium: New Therapies and Diagnostic Techniques for Respiratory Disease,
Kuethe, D. O., R. Montaño, and
N. L. Adolphi, Imaging
lung tissue is not so difficult. 7th
International Conference on Magnetic Resonance Microscopy, Snowbird,
Dean O. Kuethe, R. E. Botto, J.
Quintana, N. Adolphi, and
Adolphi, N. L. and D. O. Kuethe, First T1 images of
inert fluorinated gases in lungs. 7th
International Conference on Magnetic Resonance Microscopy, Snowbird,
Kuethe, D. O., N. L. Adolphi,
and R. Montaño, FID
projection pulse sequences for imaging lung tissue and inflammation. International Society of Magnetic Resonance
in Medicine,
Kuethe, D. O., and R. Montaño,
Lung MRI: physics solution to an important problem. Center for Advanced Studies
Workshop,
Kuethe, D.
O., Quantitative pulmonary functional MRI of rat lungs with SF6.
International Workshop on Pulmonary Functional Imaging,
Kuethe, D.
O., Counter-intuitive improvements in FID projection imaging of SF6 in lungs. International Society of Magnetic Resonance
in Medicine,
Beyea, S. D., A. Caprihan, D.
O. Kuethe, S. J. Glass, and A. DiGiovanni, Non-destructive determination of
space resolved BET surface area in partially sintered ceramics using nuclear
magnetic resonance imaging (NMRI), 104th Annual Meeting of The American Ceramic
Society, St. Louis, April 28-May 1, 2002.
Caprihan, A., S. D. Beyea, D.
O. Kuethe, S. J. Glass, and A. DiGiovanni, Gas magnetic resonance imaging (MRI)
of porous ceramics, 104th Annual Meeting of The American Ceramic Society, St.
Louis, April 28-May 1, 2002.
Codd, S. L., S. A. Altobelli,
and D. O. Kuethe, “Gas flows through porous media studied by thermally
polarized fluorinated and protonated gases, 43rd Experimental Nuclear Magnetic
Resonance Conference,
Beyea, S. D., A. Caprihan, D.
O. Kuethe, S. J. Glass, and A. DiGiovanni, Thermally polarized gas NMR imaging
for characterization of nanoporous solids, 43rd Experimental Nuclear Magnetic
Resonance Conference, Pacific Grove, CA, April, 2002.
Kuethe, D.
O., and T. Pietraß. T1s of inert fluorinated gases are sufficiently
predictable to aid quantitative imaging. 6th International Conference on
Magnetic Resonance Microscopy,
Kuethe, D. O., A. Caprihan, C.
F. M. Clewett, and T. Pietraß, NMR relaxation of inert fluorinated gases good
for studying porous media. Center for Advanced Studies Workshop,
Altobelli, S. A., A. Caprihan,
E. Fukushima, D. O. Kuethe, Thermally
polarized gas NMR imaging of porous materials, 5th International Meeting in
Recent Advances in MR Applications to Porous Media, Bologna, Italy, October,
2000.
Caprihan, A.,
C. F. M. Clewett, D. O. Kuethe,
Kuethe, D. O. Respiratory imaging using
CF4, SF6, and related gases.
Environmental Molecular Sciences Laboratory Symposia 2000,
Kuethe, D.
O., A. Caprihan, H. M. Gach, I. J. Lowe, and
Kuethe, D. O., A. Caprihan, H.
M. Gach, I. J. Lowe, J. A. Loeppky, and E. Fukushima. Imaging SF6 in lungs as an
index to gas exchange: something useful? 5th International Conference on
Magnetic Resonance Microscopy,
Behr, V. C., D. O. Kuethe, and
Kuethe, D. O., A. Caprihan, H.
M. Gach, I. J. Lowe, N. C. Staub, and E. Fukushima. Imaging obstructed ventilation with inert
fluorinated gases. International Society of Magnetic Resonance in Medicine
meeting,
Kuethe, D. O., A. Caprihan, H.
M. Gach, I. J. Lowe, J. A. Loeppky, N. C. Staub, and E. Fukushima. Imaging
ventilation-to-perfusion ratios. Hypoxia Symposium, Jasper
Kuethe, D.
O., A. Caprihan, E. Fukushima, H. M. Gach,
Caprihan, A., E. Fukushima, and
D. O. Kuethe, Porous media studies by gas NMR, AMPERE Workshop on Porous
Systems and Systems with Restricted Geometry,
Kuethe, D. O., P. Morris. Exposing the H in an H-free coil. The NMR Newsletter, No. 480:33-34, 1998.
Kuethe, D.
O., A. Caprihan, E. Fukushima, H. M. Gach, and
Altobelli, S. A., A. Caprihan,
E. Fukushima, D. O. Kuethe, J. D. Seymour.
NMR studies of fluid structure, flow, and diffusion. American Physical Society
Kuethe, D.
O., A. Caprihan, E. Fukushima, H. M. Gach, and
Kuethe, D. O., A. Caprihan, E.
Fukushima, R. A. Waggoner, H. M. Gach, and I. J. Lowe. Imaging lungs using inert
fluorinated gases. International Society of Magnetic Resonance in
Medicine meeting,
Kuethe, D.
O., C. Gasparovic, A. Bee, and T. Kellywood. Will inert fluorocarbon gases tell us
intracellular oxygen concentrations? Hypoxia Symposium,
Loeppky, J. A., D. O. Kuethe,
S. A. Altobelli, R. C. Roach, M. Icenogle, and P. Scotto. Is the increase in ventilation with hypoxia
affected by gas density? Hypoxia
Symposium,
Kuethe, D.
O., A. Caprihan, E. Fukushima, H. M. Gach, and
Kuethe, D.
O., A. Caprihan, and R. A. Waggoner.
Imaging inert fluorinated gases in lungs.
Kuethe, D.
O., A. Caprihan, and R. A. Waggoner Imaging SF6 and C2F6 in lungs. 37th
Experimental Nuclear Magnetic Resonance Conference,
Kuethe, D. O. NMR signal loss
from turbulence: test of theories. 36th Experimental Nuclear Magnetic Resonance
Conference,
Wang, L. Z.,
S. A. Altobelli, D. O. Kuethe, and
Kuethe, D.
O., J. A. Loeppky, and G. Malvin.
Nucleate vs. enucleate red blood cells: rate of acid accumulation in
whole blood. Hypoxia Symposium,
Zientara, G.
P., L. P. Panych, and D. O. Kuethe.
1994
Dynamically adaptive MRI pulse sequence method using the SVD. J.
Mag. Res. Imag. 4(P):38.
Gao,
J.-H., D. O. Kuethe. 1994 Measuring correlation time of
turbulence using NMR technique. J. Mag. Res. Imag. 4(P):121.
Gao,
J.-H., D. O. Kuethe, and L. J. Neuringer.
Mapping turbulent intensity by NMR imaging. Society of Magnetic Resonance in Medicine meeting,
Stabb, J. S.,
J. J. Knapik, S. A. Smith, D. O. Kuethe, and L. J. Neuringer. The relationship between
muscle strength and muscle cross sectional area determined by magnetic
resonance imaging. American College Sports Medicine meeting, 1993.
Gao,
J.-H., D. O. Kuethe, and L. J. Neuringer.
1993 Phase
contrast method in turbulent flow velocity measurement. J. Mag. Res. Imag. 3(P):125.
Gao,
J.-H., D. O. Kuethe, and L. J. Neuringer.
1992 Time
course of NMR signal loss due to turbulent flow. J. Mag. Res. Imag. 2(P):142.
Gao,
J.-H., D. O. Kuethe, and L. J. Neuringer.
1992 Turbulent
flow measurements by nuclear magnetic resonance. Bull. Amer. Phys. Soc. 37(9):1870.
Kuethe, D. O. & L. J.
Neuringer. Measuring
anisotropic turbulent diffusion. Society of Magnetic
Resonance in Medicine meeting,
Kuethe, D. O.
Measuring distributions of eddy diffusivity with magnetic resonance imaging. Seventh Symposium on Turbulent Shear Flows,
Kuethe, D. O. Measurements of
turbulent diffusivity with magnetic resonance imaging may be useful for
characterizing cardiovascular disease. Canadian Assoc. Physicists, Div. Med.
& Biol. Phys. meeting,
Kuethe, D. O., K. W. Small,
& R. A. Blinder. Dynamic similarity
applied to the Maxwell equations to determine if patients with metallic tacks
in their eyes are safe in large magnets. C. A. P., Div. Med. & Biol. Phys.
London, ON, June 1989.
Kuethe, D. O.
and O. B. Boyko.
"Ghosts" of blood vessels mimic breaches in the blood-brain
barrier in gadolinium enhanced MR images. Association of
University Radiologists meeting, Seattle, May 1989.
Kuethe, D.
O., K. W. Small and R. A. Blinder.
Are large magnetic fields safe for patients with metallic retinal tacks?
A. U. R. meeting, Seattle, May 1989.
Kuethe, D. O. 1989. Measuring distributions of diffusivity in turbulent fluids with
magnetic resonance imaging. Bull. Amer. Phys. Soc. 34(3):739.
Kuethe, D. O. & R. J.
Herfkens. Fluid shear: quantifying
signal changes caused by known shear rates. Society of
Magnetic Resonance in Medicine meeting,
Kuethe, D. O. & R. J.
Herfkens. Fluid shear
and magnetic resonance imaging. Association of
University Radiologists meeting,
Kuethe, D. O. 1985. Fluid mechanical valving of air flow in bird lungs. American Zoologist. 25:117A.
Patent
Gresser; J. D.,
Wise, D. L., Jimoh, A. G., Augenstein, D. C., Kuethe, D. O., Trantolo, D.
J. Biodegradable bursting release
system, U. S.
Patent number 5,429,822. July 4, 1995.
Awards
Best Student Paper Award, 1985
meeting of American Society of Zoologists
Cocos Fellow,
NIH Trainee, Fall 1981 through Summer 1984
Invited Lectures
MR imaging of lungs is not only
possible — it can be rather good, Center for Magnetic Resonance Research,
Imaging ventilation-to-perfusion
ratios with NMR imaging of inert fluorinated gases, International Workshop on Pulmonary
Functional Imaging at Penn,
Imaging lungs and SF6 gas in
lungs with magnetic resonance,
Imaging lungs
with NMR. Bioengineering
Dept., Pennsylvania State Univ., State College PA, and Center for NMR Research,
Hershey PA, November 2003.
Imaging
ventilation-perfusion ratios and other physiological quantities with SF6 or
other (polarized noble) gases. Hyperpolarized Gas Study Group, International Society of Magnetic
Resonance in Medicine meeting,
Imaging lung
physiology with NMR.
Respiratory
imaging using CF4, SF6, and related gases. Environmental Molecular Sciences Laboratory
Symposia 2000,
Imaging SF6 in lungs as an
index to gas exchange: something useful? 5th International Conference on
Magnetic Resonance Microscopy,
Making pictures of almost
nothing in lungs with a big magnet and radio waves.
Imaging obstructed ventilation
in lungs using inert fluorinated gases. 4th International Conference on
Magnetic Resonance Microscopy and Macroscopy,
Imaging inert
fluorinated gases in lungs with NMR. Univ. of Pittsburgh/Carnegie Mellon
Univ.,
Imaging inert
fluorinated gases in lungs with NMR.
Brain
capillary density at high altitude in people and rats.
NMR signal loss from
turbulence. Univ. of Pittsburgh/Carnegie
Mellon Univ.,
Moving the
NMR imaging frame. MIT,
Symposium, Future Directions in Biomedical Magnetic Resonance, in memory of Leo
Neuringer, Oct. 1993.
Fluid
mechanical valving of air flow in bird lungs. Museum of Comparative Zoology,
Review Articles for
Physical Review Letters
Physical Review E
Magnetic Resonance in Medicine
Journal of Applied Physiology
Have reviewed articles for
American Journal of Physiology
European Journal of Clinical
Investigation
IEEE TBE
Academic Radiology
Investigative Radiology
Solar Energy
Students and Post-Docs
Avery Evans, Medical Student on
research rotation,
Jai-Hong Gao,
Post-Doc, Massachusetts Institute of Technology 1992-1993
Volker C.
Behr, Masters, Physics,
Rebecca Montaño, Physics,
University of New Mexico, 2002-2006
Summer Interns at LRRI:
1995
Jake Ingram,
Josef Mikeska,
Samad Hashimi,
1996
Angelita Bee,
Timothy Kellywood,
1998
Priscilla Tsosie,
Jorge Silva-Banuelos,
1999
Stephanie Begay,
Summer Interns at NMR:
2001
Louanna Van Winkle,
2002